Acute bronchitis is suspected in patients with an acute onset but persistent cough who do not have clinical findings suggestive of pneumonia (eg, fever, tachypnea, rales, signs of parenchymal consolidation) and do not have chronic obstructive pulmonary disease. For most patients, the diagnosis can be made based upon the history and physical examination. Testing for COVID-19 is recommended for all patients during the COVID-19 pandemic. Otherwise, testing is generally reserved for cases in which pneumonia is suspected, the clinical diagnosis is uncertain, or when results would change management (eg, a positive influenza test result in a patient who meets criteria for antiviral therapy). For most patients with acute bronchitis, symptoms are self-limited, resolving in about one to three weeks. Reassurance and symptom control are the cornerstones of care. Antibiotics are not recommended for routine use. By definition, acute bronchitis occurs in the absence of chronic obstructive pulmonary disease (COPD). Symptoms of acute bronchitis that occur in patients with COPD typically indicate an acute exacerbation of COPD, which is managed differently.